LANDMARK PAPERS

SEPSIS-3

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Singer M, Deutschman CS, Seymour CW, et al. The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). JAMA. 2016;315(8):801–810. doi:10.1001/jama.2016.0287

PEPTIC RCT

PPI or H2-blocker for Ulcer Prophylaxis?

Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial. JAMA. 2020 Jan 17. doi: 10.1001/jama.2019.22190. [Epub ahead of print]

EXTEND

Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke

Ma H, Campbell BCV, Parsons MW, et al. Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke. N Engl J Med. 2019;380(19):1795-1803. doi:10.1056/NEJMoa1813046

USG VS CT

Ultrasonography versus computed tomography for suspected nephrolithiasis

Smith-Bindman R, Aubin C, Bailitz J, et al. Ultrasonography versus computed tomography for suspected nephrolithiasis. N Engl J Med. 2014;371(12):1100-1110. doi:10.1056/NEJMoa1404446